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Elín Soffía Ólafsdóttir - Prófessor

Elín Soffía Ólafsdóttir

–

Heilbrigðisvísindasvið

Elín Soffía Ólafsdóttir

Prófessor

Prófessor í lyfja- og efnafræði náttúruefna

Aðsetur
Hagi / Ha-315
Sími
5255804
Tölvupóstur
elinsol [hjá] hi.is

Starfseining
Lyfjafræðideild kennsla/rekstur

ORCID vefsíða
https://orcid.org/0000-0001-7305-7129
Rannsóknagátt – Elín Soffía Ólafsdóttir
Í vinnslu út haustmisseri 2023

Útgefið efni

2023

Flustramine Q, a Novel Marine Origin Acetylcholinesterase Inhibitor from Flustra foliaceaFuture Pharmacology

2022

Novel methods to characterise spatial distribution and enantiomeric composition of usnic acids in four Icelandic lichensPhytochemistry

2020

Structure-based discovery of dual-target hits for acetylcholinesterase and the α7 nicotinic acetylcholine receptors: In silico studies and in vitro confirmationMolecules
Phylogenetic diversity of the lichenized algal genus Trebouxia (Trebouxiophyceae, Chlorophyta): a new lineage and novel insights from fungal-algal association patterns of Icelandic cetrarioid lichens (Parmeliaceae, Ascomycota)Botanical Journal of the Linnean Society

2019

Novel approach for the search for chemical scaffolds with dual activity with acetylcholinesterase and the α7 nicotinic acetylcholine receptor—a perspective for the treatment of neurodegenerative disordersMolecules
Infraspecific Variation of Huperzine A and B in Icelandic Huperzia selago ComplexPlanta Medica
Alkaloid fingerprinting resolves Huperzia selago genotypes in IcelandBiochemical Systematics and Ecology
Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cellsFree Radical Biology and Medicine
Exopolysaccharides from Cyanobacterium aponinum induce a regulatory dendritic cell phenotype and inhibit SYK and CLEC7A expression in dendritic cells, T cells and keratinocytesInternational Immunopharmacology
Ethnopharmacology of the club moss subfamily Huperzioideae (Lycopodiaceae, Lycopodiophyta): A phylogenetic and chemosystematic perspectiveJournal of Ethnopharmacology

2018

Galantamine is not a positive allosteric modulator of human α4β2 or α7 nicotinic acetylcholine receptorsBritish Journal of Pharmacology
Authentication of Iceland Moss (Cetraria islandica) by UPLC-QToF-MS chemical profiling and DNA barcodingFood Chemistry

2017

Investigations on the constituents of SagaPro tablets, a food supplement manufactured from Angelica archangelica leafPharmazie
DNA barcoding and LC-MS metabolite profiling of the lichen-forming genus Melanelia: Specimen identification and discrimination focusing on Icelandic taxaPLOS ONE

2016

Secondary metabolites from cetrarioid lichens: Chemotaxonomy, biological activities and pharmaceutical potentialPhytomedicine
Effects of exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland on anti-CD3/anti-CD28 stimulated T cellsScandinavian Journal of Immunology

2015

The Genus Diphasiastrum and Its Lycopodium AlkaloidsPlanta Medica
Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17(+)ROR gamma t(+)/IL-10(+)FoxP3(+) ratio in CD4(+) T cellsImmunology Letters
Virtual screening for new lead compounds for Alzheimer's disease with dual mode of actionPlanta Medica
Dendritic cells matured in the presence of the lycopodium alkaloid annotine direct T cell responses toward a Th2/Treg phenotypePhytomedicine

2014

A heteroglycan from the cyanobacterium Nostoc commune modulates LPS-induced inflammatory cytokine secretion by THP-1 monocytes through phosphorylation of ERK1/2 and AktPhytomedicine

2013

Lycopodium alkaloids: PharmacologyNatural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes
Structural characterisation of a complex heteroglycan from the cyanobacterium Nostoc communeCarbohydrate Polymers
A Heteroglycan from the Cyanobacterium Nostoc Commune Affects THP-1 Monocyte Cytokine Secretion and Map and Akt Kinase ActivationScandinavian Journal of Immunology
Phytochemical analysis of alkaloids from the Icelandic club moss Diphasiastrum alpinumPhytochemistry Letters
Biodiversity of benthic invertebrates and bioprospecting in Icelandic watersPhytochemistry Reviews

2012

Virtual screening for new lead compounds for Alzheimer's disease with dual mode of actionPlanta Medica
Immunomodulating effects of exopolysaccharides produced by a cyanobacterium from the Blue Lagoon in IcelandImmunology
Phytochemical analysis of alkaloids from the icelandic club moss Diphasiastrum alpinum (L.) HolubPlanta Medica
Marchantin A, a macrocyclic bisbibenzyl ether, isolated from the liverwort Marchantia polymorpha, inhibits protozoal growth in vitroPhytomedicine
Synergistic Cytotoxic Effect of the Microtubule Inhibitor Marchantin A from Marchantia polymorpha and the Aurora Kinase Inhibitor MLN8237 on Breast Cancer Cells In VitroPlanta Medica

2011

The Effect of Polysaccharides from Icelandic Lichens and Cyanobacteria on Cytokine Secretion by THP-1 CellsScandinavian Journal of Immunology
Ethanol extract from birch bark (Betula pubescens) suppresses human dendritic cell mediated Th1 responses and directs it towards a Th17 regulatory response in vitroImmunology Letters

2010

Acetylcholinesterase inhibitory activity of lycopodane-type alkaloids from the Icelandic Lycopodium annotinum ssp alpestrePhytochemistry
Structural characterisation of a new O-methylated heteroglycan, colleman, from the cyanolichen Collema flaccidumCarbohydrate Polymers

2008

In vitro and in vivo immunomodulating effects of traditionally prepared extract and purified compounds from Cetraria islandicaInternational Immunopharmacology
Anti-plasmodial activity of extracts of five species of Icelandic liverwortsPlanta Medica
Alkaloid content of the Icelandic club moss Lycopodium annotinum - acetylcholinesterase inhibitory activity in vitroPlanta Medica
In vitro and in vivo immunomodulating effects of traditionally-prepared extract and purified compounds from Cetraria islandicaProceedings of the Nutrition Society

2007

Immunomodulating polysaccharides from the lichen Thamnolia vermicularis var. subuliformisPhytomedicine
In vitro and in vivo immuno-modulating effects of water-soluble extract and purified polysaccharides and secondary metabolites derived from the lichen Cetraria islandicaScandinavian Journal of Immunology

2006

Alkaloids from the club moss Lycopodium annotinum L. - acetylcholinesterase inhibitory activity in vitroPlanta Medica
Structural characterization of two galactofuranomannan isolated from the lichen thamnolia vermicularis var. subuliformisPlanta Medica
Structural characterisation of novel lichen heteroglycans by NMR spectroscopy and methylation analysisCarbohydrate Research
Immunomodulating effects of lichen-derived polysaccharides on monocyte-derived dendritic cellsInternational Immunopharmacology
Immunomodulating effects of lichen-derived polysaccharides on monocyte-derived dendritic cellsPlanta Medica
Structural characterisation of a highly branched galactomannan from the lichen Peltigera canina by methylation analysis and NMR-spectroscopyCarbohydrate Polymers

2005

Effects of lichen heteroglycans on proliferation and IL-10 secretion by rat spleen cells and IL-10 and TNF-alpha secretion by rat peritoneal macrophages in vitroPhytomedicine

2004

Selagoline, a new alkaloid from Huperzia selagoNatural Product Research

2003

Immunologically active O6-branched (1 -> 3)-beta-glucan from the lichen Thamnolia vermicularis var. subuliformisPhytomedicine

2002

Chromatography and electrophoresis in separation and characterization of polysaccharides from lichensJournal of Chromatography a
Natural cyclopentanoid cyanohydrin glycosides, part 23. Cyanohydrin glycosides of Passiflora: distribution pattern, a saturated cyclopentane derivative from P-guatemalensis, and formation of pseudocyanogenic alpha-hydroxyamides as isolation artefactsPhytochemistry
Cyanogenesis in glucosinolate-producing plants: Carica papaya and Carica quercifoliaPhytochemistry

2001

Polysaccharides from lichens: Structural characteristics and biological activityPlanta Medica
Constituents of three Icelandic Alchemilla speciesBiochemical Systematics and Ecology

1999

Rhamnopyranosylgalactofuranan, a new immunologically active polysaccharide from Thamnolia subuliformisPhytomedicine
Rhamnopyranosylgalactofuranan, a new immunologically active polysaccharide from Thamnolia subuliformisPhytomedicine
Immunologically active (1→3)-(1→4)-α-D-Glucan from Cetraria islandicaPhytomedicine
Immunologically active (1 -> 3)-(1 -> 4)-alpha-D-glucan from Cetraria islandicaPhytomedicine

1992

SUBSTRATE-SPECIFICITY IN THE BIOSYNTHESIS OF CYCLOPENTANOID CYANOHYDRIN GLUCOSIDESPhytochemistry

1991

NATURAL CYCLOPENTANOID CYANOHYDRIN GLYCOSIDES .13. STRUCTURE DETERMINATION OF NATURAL EPOXYCYCLOPENTANES BY X-RAY CRYSTALLOGRAPHY AND NMR-SPECTROSCOPYJournal of Organic Chemistry
NATURAL CYCLOPENTANOID CYANOHYDRIN GLYCOSIDES .12. CYANOHYDRIN GLYCOSIDES WITH UNUSUAL SUGAR RESIDUES - REVISED STRUCTURE OF PASSITRIFASCIATINPhytochemistry

1990

CYCLOPENTANOID CYANOHYDRIN GLYCOSIDES .11. CYANOHYDRIN GLUCOSIDES OF TURNERACEAEBiochemical Systematics and Ecology

1989

NATURAL CYCLOPENTENOID CYANOHYDRIN GLYCOSIDES .8. CYCLOPENTENOID CYANOHYDRIN GLYCOSIDES WITH UNUSUAL SUGAR RESIDUESActa Chemica Scandinavica
CYANOHYDRIN GLYCOSIDES OF PASSIFLORACEAE .9.Phytochemistry

1987

Monohydroxylated cyclopentenone cyanohydrin glucosides of flacourtiaceaePhytochemistry
NATURAL CYCLOPENTENOID CYANOHYDRIN GLYCOSIDES .3. CYANOGENESIS OF ADENIA-VOLKENSII HARMS AND TETRAPATHAEA-TETRANDRA CHEESEMAN (PASSIFLORACEAE) REVISITED - TETRAPHYLLIN-B AND VOLKENIN - OPTICAL-ROTATORY POWER OF CYCLOPENTENOID CYANOHYDRIN GLUCOSIDESActa Chemica Scandinavica Series B-Organic Chemistry and Biochemistry
CYCLOPENTENOID CYANOHYDRIN GLYCOSIDES .5. MONOHYDROXYLATED CYCLOPENTENONE CYANOHYDRIN GLUCOSIDES OF FLACOURTIACEAEPhytochemistry

1986

NATURAL GLYCOSIDES OF CYCLOPENTENONE CYANOHYDRINS .2. REVISED STRUCTURE OF SO-CALLED EPITETRAPHYLLIN-BTetrahedron Letters

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