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Sædís Sævarsdóttir - Professor

Sædís Sævarsdóttir

–

Heilbrigðisvísindasvið

Sædís Sævarsdóttir

Professor

Professor and Vice Head of the Faculty of Medicine, consultant in rheumatology at Landspitali University Hospital, project leader at deCODE genetics

Location
Sturlugata 8
Phone
5701900
Email
saedis [at] hi.is

Unit
Faculty of Medicine

Published works

2023

Evaluation of an individually tailored smoking-cessation intervention for patients with rheumatoid arthritis in an outpatient clinicScandinavian Journal of Rheumatology
Meta-analysis of erosive hand osteoarthritis identifies four common variants that associate with relatively large effectAnnals of the Rheumatic Diseases
Comorbidities and chance of remission in patients with early rheumatoid arthritis receiving methotrexate as first-line therapy: a Swedish observational nationwide studyRMD Open
Disease‐modifying antirheumatic drugs and risk of thyroxine‐treated autoimmune thyroid disease in patients with rheumatoid arthritisJournal of Internal Medicine
Genome-wide investigation of persistence to treatment with methotrexate in early rheumatoid arthritis.Rheumatology (Oxford, England)
In early rheumatoid arthritis, anticitrullinated peptide antibodies associate with low number of affected joints and rheumatoid factor associates with systemic inflammationAnnals of the Rheumatic Diseases
Sequence variant affects GCSAML splicing, mast cell specific proteins, and risk of urticaria.Communications biology
Large-scale plasma proteomics comparisons through genetics and disease associationsNature
Deficit of homozygosity among 1.52 million individuals and genetic causes of recessive lethality.Nature communications
Remission, response, retention and persistence to treatment with disease-modifying agents in patients with rheumatoid arthritis: a study of harmonised Swedish, Danish and Norwegian cohorts.RMD open

2022

Sleep problems in rheumatoid arthritis over 12 years from diagnosis: results from the Swedish EIRA study.RMD open
Established risk loci for systemic lupus erythematosus at NCF2, STAT4, TNPO3, IRF5 and ITGAM associate with distinct clinical manifestations: A Danish genome-wide association study.Joint bone spine
Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subset.Annals of the rheumatic diseases
A genome-wide meta-analysis identifies 50 genetic loci associated with carpal tunnel syndromeNature Communications
Combined Conventional Synthetic Disease Modifying Therapy vs. Infliximab for Rheumatoid Arthritis: Emulating a Randomized Trial in Observational Data.Clinical pharmacology and therapeutics
Antibodies to a Citrullinated Porphyromonas gingivalis Epitope Are Increased in Early Rheumatoid Arthritis, and Can Be Produced by Gingival Tissue B Cells: Implications for a Bacterial Origin in RA Etiology.Frontiers in immunology
A genome-wide meta-analysis identifies 53 sequence variants associating with carpal tunnel syndrome
Does persistence to methotrexate treatment in early rheumatoid arthritis have a familial component?Arthritis research & therapy
Neither low social support nor low decision latitude at work is associated with disease remission among patients with rheumatoid arthritis: results from the Swedish EIRA study.Arthritis research & therapy
The CRTAC1 protein in plasma associates with prevalent osteoarthritis and predicts future risk as well as progression to joint replacements - Results from the UK Biobank resource.Arthritis & rheumatology (Hoboken, N.J.)
HLA alleles, disease severity, and age associate with T-cell responses following infection with SARS-CoV-2.Communications biology
Comorbidities and treatment patterns in early rheumatoid arthritis: a nationwide Swedish studyRMD Open
The association between autoantibodies and risk for venous thromboembolic events among patients with rheumatoid arthritis.Rheumatology (Oxford, England)

2021

A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo.Communications biology
Genetic variants associated with platelet count are predictive of human disease and physiological markers.Communications biology
Large-scale integration of the plasma proteome with genetics and disease.Nature genetics
Validation of the adjusted multi-biomarker disease activity score as a prognostic test for radiographic progression in rheumatoid arthritis: a combined analysis of multiple studies.Arthritis research & therapy
Social stressors and risk of rheumatoid arthritis and their relationship to known modifiable risk factors: results from the Swedish EIRA study.Scandinavian journal of rheumatology
Rheumatoid arthritis autoantibodies and their association with age and sex.Clinical and experimental rheumatology
Mortality over 14 years in MTX-refractory patients randomized to a strategy of addition of infliximab or sulfasalazine and hydroxychloroquine.Rheumatology (Oxford, England)
Comorbidities at diagnosis of rheumatoid arthritis: a population-based case-control study.Rheumatology (Oxford, England)
A Comprehensive Evaluation of the Relationship Between Different IgG and IgA Anti-Modified Protein Autoantibodies in Rheumatoid Arthritis.Frontiers in immunology
The CRTAC1 protein in plasma associates with osteoarthritis and predicts progression to joint replacements: a large-scale proteomics scan in Iceland.Arthritis & rheumatology (Hoboken, N.J.)
Is tea consumption associated with reduction of risk of rheumatoid arthritis? A Swedish case-control study.Arthritis research & therapy

2020

Anti-citrullinated protein antibody specificities, rheumatoid factor isotypes and incident cardiovascular events in patients with rheumatoid arthritis.Arthritis & rheumatology (Hoboken, N.J.)
Does autoimmune thyroid disease affects rheumatoid arthritis disease activity or response to methotrexate?RMD open
Presence of autoantibodies in "seronegative" rheumatoid arthritis associates with classical risk factors and high disease activity.Arthritis research & therapy
Drug Tolerant Anti-drug Antibody Assay for Infliximab Treatment in Clinical Practice Identifies Positive Cases Earlier.Frontiers in immunology
Association of serum anti-centromere protein F antibodies with clinical response to infliximab in patients with rheumatoid arthritis: A prospective study.Seminars in arthritis and rheumatism
Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women.Nature communications
FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid disease.Nature
Pain over 2 years after start of biological versus conventional combination treatment in early rheumatoid arthritis: results from the randomised controlled SWEFOT trial.Arthritis care & research
Abatacept in rheumatoid arthritis: survival on drug, clinical outcomes, and their predictors-data from a large national quality register.Arthritis research & therapy
Occupational physical workload and development of anti-collagen type II antibodies in rheumatoid arthritis: results from the Swedish EIRA population-based case-control study.Clinical and experimental rheumatology
The importance of differences; On environment and its interactions with genes, and immunity in the causation of rheumatoid arthritis.Journal of internal medicine

2019

Occupational exposure to asbestos and silica and risk of developing rheumatoid arthritis: findings from a Swedish population-based case-control study.RMD open
Periodontal Health and Oral Microbiota in Patients with Rheumatoid Arthritis.Journal of clinical medicine
Association of response to TNF inhibitors in rheumatoid arthritis with quantitative trait loci for CD40 and CD39.Annals of the rheumatic diseases
Predicting risk for radiographic damage in rheumatoid arthritis: comparative analysis of the multi-biomarker disease activity score and conventional measures of disease activity in multiple studies.Current medical research and opinion
Serum Biomarkers for Prediction of Response to Methotrexate Monotherapy in Early Rheumatoid Arthritis: Results from the SWEFOT Trial.The Journal of rheumatology
Association of female sex and positive rheumatoid factor with low serum infliximab and anti-drug antibodies, related to treatment failure in early rheumatoid arthritis: results from the SWEFOT trial population.Scandinavian journal of rheumatology
An updated matrix to predict rapid radiographic progression of early rheumatoid arthritis patients: pooled analyses from several databases.Rheumatology (Oxford, England)

2018

Risk of Thyroxine-Treated Autoimmune Thyroid Disease Associated With Disease Onset in Patients With Rheumatoid Arthritis.JAMA network open
Incidence and risk factors for adalimumab and infliximab anti-drug antibodies in rheumatoid arthritis: A European retrospective multicohort analysis.Seminars in arthritis and rheumatism
Anti-Carbamylated Protein Antibodies and Higher Baseline Disease Activity in Rheumatoid Arthritis-A Replication Study in Three Cohorts: Comment on the Article by Truchetet et al.Arthritis & rheumatology (Hoboken, N.J.)
Smoking and response to rituximab in rheumatoid arthritis: results from an international European collaboration.Scandinavian journal of rheumatology

2017

A Multi-Biomarker Disease Activity Score and the Choice of Second-Line Therapy in Early Rheumatoid Arthritis After Methotrexate Failure.Arthritis & rheumatology (Hoboken, N.J.)
Anticollagen type II antibodies are associated with an acute onset rheumatoid arthritis phenotype and prognosticate lower degree of inflammation during 5 years follow-up.Annals of the rheumatic diseases
Obesity is a strong predictor of worse clinical outcomes and treatment responses in early rheumatoid arthritis: results from the SWEFOT trial.RMD open
Oral contraceptives, breastfeeding and the risk of developing rheumatoid arthritis: results from the Swedish EIRA study.Annals of the rheumatic diseases
A single nucleotide polymorphism in the NCF1 gene leading to reduced oxidative burst is associated with systemic lupus erythematosus.Annals of the rheumatic diseases

2016

Remaining Pain in Early Rheumatoid Arthritis Patients Treated With Methotrexate.Arthritis care & research
Family history of rheumatoid arthritis: an old concept with new developments.Nature reviews. Rheumatology
Association of a multibiomarker disease activity score at multiple time-points with radiographic progression in rheumatoid arthritis: results from the SWEFOT trial.RMD open
Erratum: Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.Nature communications
A genetic risk score composed of rheumatoid arthritis risk alleles, HLA-DRB1 haplotypes, and response to TNFi therapy - results from a Swedish cohort study.Arthritis research & therapy
Crowdsourced assessment of common genetic contribution to predicting anti-TNF treatment response in rheumatoid arthritis.Nature communications
Correlates of Leisure Time Physical Inactivity in a Scandinavian Population: A Basis for Interventions.Journal of physical activity & health

2015

Does a family history of RA influence the clinical presentation and treatment response in RA?Annals of the rheumatic diseases
Recent infections are associated with decreased risk of rheumatoid arthritis: a population-based case-control study.Annals of the rheumatic diseases
Serum RANKL levels associate with anti- citrullinated protein antibodies in early untreated rheumatoid arthritis and are modulated following methotrexate.Arthritis research & therapy
Brief report: enhancement of patient recruitment in rheumatoid arthritis clinical trials using a multi-biomarker disease activity score as an inclusion criterion.Arthritis & rheumatology (Hoboken, N.J.)
Higher education is associated with a better rheumatoid arthritis outcome concerning for pain and function but not disease activity: results from the EIRA cohort and Swedish rheumatology register.Arthritis research & therapy
Postmenopausal hormone therapy and the risk of rheumatoid arthritis: results from the Swedish EIRA population-based case-control study.European journal of epidemiology
Parity influences the severity of ACPA-negative early rheumatoid arthritis: a cohort study based on the Swedish EIRA material.Arthritis research & therapy

2014

Patients with regular physical activity before onset of rheumatoid arthritis present with milder disease.Annals of the rheumatic diseases
Response to: 'Obesity and comorbidity are independently associated with a failure to achieve remission in patients with established rheumatoid arthritis' by Ellerby et al.Annals of the rheumatic diseases
Accelerating translational research by clinically driven development of an informatics platform--a case study.PloS one
Overweight decreases the chance of achieving good response and low disease activity in early rheumatoid arthritis.Annals of the rheumatic diseases
Current smoking status is a strong predictor of radiographic progression in early rheumatoid arthritis: results from the SWEFOT trial.Annals of the rheumatic diseases
Changes in the anticitrullinated peptide antibody response in relation to therapeutic outcome in early rheumatoid arthritis: results from the SWEFOT trial.Annals of the rheumatic diseases
Pretreatment multi-biomarker disease activity score and radiographic progression in early RA: results from the SWEFOT trial.Annals of the rheumatic diseases

2013

Crowdsourcing genetic prediction of clinical utility in the Rheumatoid Arthritis Responder Challenge.Nature genetics
Evaluation of hand bone loss by digital X-ray radiogrammetry as a complement to clinical and radiographic assessment in early rheumatoid arthritis: results from the SWEFOT trial.BMC musculoskeletal disorders
Thyroxin substitution and the risk of developing rheumatoid arthritis; results from the Swedish population-based EIRA study.Annals of the rheumatic diseases
Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis.PLoS genetics
Identification of anticitrullinated protein antibody reactivities in a subset of anti-CCP-negative rheumatoid arthritis: association with cigarette smoking and HLA-DRB1 'shared epitope' alleles.Annals of the rheumatic diseases
Use of 3 Dimensional Models and Navigation System in Preparation for Brain Surgery.Biomedizinische Technik. Biomedical engineering

2012

Genome-wide association analysis of anti-TNF drug response in patients with rheumatoid arthritis.Annals of the rheumatic diseases
Patterns of interaction between genetic and nongenetic attributes and methotrexate efficacy in rheumatoid arthritis.Pharmacogenetics and genomics
Very high levels of anti-citrullinated protein antibodies are associated with HLA-DRB1*15 non-shared epitope allele in patients with rheumatoid arthritis.Arthritis and rheumatism
Influence of FCGR3A genotype on the therapeutic response to rituximab in rheumatoid arthritis: an observational cohort study.BMJ open

2011

Patients with early rheumatoid arthritis who smoke are less likely to respond to treatment with methotrexate and tumor necrosis factor inhibitors: observations from the Epidemiological Investigation of Rheumatoid Arthritis and the Swedish Rheumatology Register cohorts.Arthritis and rheumatism
Mannan Binding Lectin (MBL) genotypes coding for high MBL serum levels are associated with rheumatoid factor negative rheumatoid arthritis in never smokers.Arthritis research & therapy
In early rheumatoid arthritis, patients with a good initial response to methotrexate have excellent 2-year clinical outcomes, but radiological progression is not fully prevented: data from the methotrexate responders population in the SWEFOT trial.Annals of the rheumatic diseases

2010

Predictors of response to methotrexate in early DMARD naive rheumatoid arthritis: results from the initial open-label phase of the SWEFOT trial.Annals of the rheumatic diseases
Rheumatoid arthritis risk allele PTPRC is also associated with response to anti-tumor necrosis factor alpha therapy.Arthritis and rheumatism

2008

Low serum mannose-binding lectin level increases the risk of death due to pneumococcal infection.Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Association of three systemic lupus erythematosus susceptibility factors, PD-1.3A, C4AQ0, and low levels of mannan-binding lectin, with autoimmune manifestations in Icelandic multicase systemic lupus erythematosus families.Arthritis and rheumatism

2007

Mannan-binding lectin may facilitate the clearance of circulating immune complexes--implications from a study on C2-deficient individuals.Clinical and experimental immunology
Patients with rheumatoid arthritis have higher levels of mannan-binding lectin than their first-degree relatives and unrelated controls.The Journal of rheumatology

2006

Mannan-binding lectin and complement C4A in Icelandic multicase families with systemic lupus erythematosus.Annals of the rheumatic diseases

2005

[Postgraduate medical education in Iceland; medical students' and residents' attitude].Laeknabladid

2004

Human plasma-derived mannose-binding lectin: a phase I safety and pharmacokinetic study.Scandinavian journal of immunology
The potential role of mannan-binding lectin in the clearance of self-components including immune complexes.Scandinavian journal of immunology
Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk.The Journal of experimental medicine

2001

Low mannose binding lectin predicts poor prognosis in patients with early rheumatoid arthritis. A prospective study.The Journal of rheumatology

Keywords for Specialisation:

Genetic epidemiology

Precision medicine

Personalised medicine