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Jóna Freysdóttir - Professor

Jóna Freysdóttir

–

School of Health Sciences

Jóna Freysdóttir

Professor

Phone
5436852 8612056
Email
jf [at] hi.is

Unit
Faculty of Medicine
Website
http://lifvisindi.hi.is/staff/jona-freysdottir

ORCID site
https://orcid.org/0000-0001-9461-182X
Research portal – Jóna Freysdóttir
Under construction throughout the autumn semester 2023

Published works

2023

Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barrettiMolecules

2022

Dietary Fish Oil Increases the Number of CD11b+CD27− NK Cells at the Inflammatory Site and Enhances Key Hallmarks of Resolution of Murine Antigen-Induced PeritonitisJournal of Inflammation Research

2021

Emu Oil and Saireito in combination reduce tumour development and clinical indicators of disease in a mouse model of colitis-associated colorectal cancer.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Keratinocytes secrete multiple inflammatory and immune biomarkers, which are regulated by LL-37, in a psoriasis mimicking microenvironmentScandinavian Journal of Immunology
Seaweed extract improves carbohydrate metabolism in overweight and obese adultsCurrent Nutrition and Food Science

2020

Bromotryptamine and Imidazole Alkaloids with Anti-inflammatory Activity from the Bryozoan Flustra foliacea.Journal of natural products
Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic AcidThe Journal of Immunology
Docosahexaenoic Acid Modulates NK Cell Effects on Neutrophils and Their Crosstalk.Frontiers in immunology

2019

Effective treatment with balneophototherapy and narrowband UVB monotherapy reduces skin homing Th17/Tc17 and Th22/Tc22 effector cells in peripheral blood in patients with psoriasisJournal of Dermatological Science
Impact of dibenzocyclooctadiene lignans from Schisandra chinensis on the redox status and activation of human innate immune system cellsFree Radical Biology and Medicine
Exopolysaccharides from Cyanobacterium aponinum induce a regulatory dendritic cell phenotype and inhibit SYK and CLEC7A expression in dendritic cells, T cells and keratinocytesInternational Immunopharmacology

2018

Natural killer cells play an essential role in resolution of antigen-induced inflammation in mice.Molecular immunology
6-Bromoindole Derivatives from the Icelandic Marine Sponge Geodia barretti: Isolation and Anti-Inflammatory ActivityMarine Drugs

2017

Lipophilic fractions from the marine sponge Halichondria sitiens decrease secretion of pro-inflammatory cytokines by dendritic cells and decrease their ability to induce a Th1 type response by allogeneic CD4+ T cells.Pharmaceutical biology

2016

Acute phase inflammation is characterized by rapid changes in plasma/peritoneal fluid N-glycosylation in miceGlycoconjugate Journal
Immunomodulatory N-acyl Dopamine Glycosides from the Icelandic Marine Sponge Myxilla incrustans Collected at a Hydrothermal Vent SitePlanta Medica
A polysaccharide fraction from Achillea millefolium increases cytokine secretion and reduces activation of Akt, ERK and NF-κB in THP-1 monocytesCarbohydrate Polymers

2015

Effect of in vitro digested cod liver oil of different quality on oxidative, proteomic and inflammatory responses in the yeast Saccharomyces cerevisiae and human monocyte-derived dendritic cells.
Differential Mobility Separation of Leukotrienes and ProtectinsAnalytical Chemistry
Dendritic cells matured in the presence of the lycopodium alkaloid annotine direct T cell responses toward a Th2/Treg phenotypePhytomedicine
Exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland increase IL-10 secretion by human dendritic cells and their ability to reduce the IL-17+RORγt+/IL-10+FoxP3+ ratio in CD4+ T cellsImmunology Letters

2014

The suppressive function of human CD8(+) iTregs is inhibited by IL-1β and TNFα.
Oxidative processes during enzymatic hydrolysis of cod protein and their influence on antioxidant and immunomodulating abilityFood Chemistry
Dietary omega-3 fatty acids enhance the B1 but not the B2 cell immune response in mice with antigen-induced peritonitisThe Journal of Nutritional Biochemistry
Murine antigen-induced inflammation—A model for studying induction, resolution and the adaptive phase of inflammationJournal of Immunological Methods
A heteroglycan from the cyanobacterium Nostoc commune modulates LPS-induced inflammatory cytokine secretion by THP-1 monocytes through phosphorylation of ERK1/2 and AktPhytomedicine
Welcome to the 42nd Annual Meeting of the Scandinavian Society for Immunology in Reykjavik, IcelandScandinavian Journal of Immunology

2013

Sulphated polysaccharide from the sea cucumber Cucumaria frondosa affect maturation of human dendritic cells and their activation of allogeneic CD4(+) T cells in vitroBioactive Carbohydrates and Dietary Fibre
Dietary fish oil reduces the acute inflammatory response and enhances resolution of antigen-induced peritonitisThe Journal of Nutritional Biochemistry
Quinolinic alkaloids from Galipea longiflora Krause suppress production of proinflammatory cytokines in vitro and control inflammation in vivo upon Leishmania infection in mice.
Dietary fish oil increases the proportion of a specific neutrophil subpopulation in blood and total neutrophils in peritoneum of mice following endotoxin-induced inflammationThe Journal of Nutritional Biochemistry
Alkaloids from Galipea longiflora Krause modify the maturation of human dendritic cells and their ability to stimulate allogeneic CD4+ T cellsInternational Immunopharmacology

2012

Biodiversity of benthic invertebrates and bioprospecting in Icelandic watersPhytochemistry Reviews
Dietary fish oil decreases the proportion of classical monocytes in blood in healthy mice but increases their proportion upon induction of inflammation.
Two circulating neutrophil populations in acute inflammation in miceInflammation Research

2011

Aqueous extracts from Menyanthes trifoliate and Achillea millefolium affect maturation of human dendritic cells and their activation of allogeneic CD4+ T cells in vitroJournal of Ethnopharmacology
Ethanol extract from birch bark (Betula pubescens) suppresses human dendritic cell mediated Th1 responses and directs it towards a Th17 regulatory response in vitroImmunology Letters

2009

Vbeta usage and T regulatory cells in children following partial or total thymectomy after open heart surgery in infancy.

2008

Do non-steroidal anti-inflammatory drugs influence chronic inflammation? The effects of piroxicam on chronic antigen-induced arthritis in rats.
In vitro and in vivo immunomodulating effects of traditionally prepared extract and purified compounds from Cetraria islandica.

2007

Orofacial granulomatosis: review on aetiology and pathogenesisJournal of Oral Pathology & Medicine
Immunomodulating polysaccharides from the lichen Thamnolia vermicularis var. subuliformisPhytomedicine
Mucosal Tolerance to KLH Reduces BSA-Induced Arthritis in Rats—An Indication of Bystander SuppressionJournal of Clinical Immunology
Oral Biopsies from Patients with Orofacial Granulomatosis with Histology Resembling Crohnʼs Disease Have a Prominent Th1 EnvironmentInflammatory Bowel Diseases

2006

Expression of cytokines, chemokines, and chemokine receptors in oral ulcers of patients with Behcet's disease (BD) and recurrent aphthous stomatitis is Th1-associated, although Th2-association is also observed in patients with BD.
Immunomodulating effects of lichen-derived polysaccharides on monocyte-derived dendritic cellsInternational Immunopharmacology
Diversity of gammadelta T cells in patients with Behcet's disease is indicative of polyclonal activation.
Evidence for extrathymic T cell maturation after thymectomy in infancy.

2005

Effects of lichen heteroglycans on proliferation and IL-10 secretion by rat spleen cells and IL-10 and TNF-alpha secretion by rat peritoneal macrophages in vitro.

2004

The influence of partial or total thymectomy during open heart surgery in infants on the immune function later in life.

2001

Antibodies to Human Thymic Epithelium Form Part of the Murine Autoreactive RepertoireDevelopmental Immunology
Expression of adhesion and activation molecules in human buccal epithelial cell lines and normal human buccal epithelium in situJournal of Oral Pathology and Medicine

1999

Gammadelta T cells in Behçet's disease (BD) and recurrent aphthous stomatitis (RAS).

1998

Characterising lectin binding to the O-linked sugars of immunoglobulin A1Biochemical Society Transactions
K21-Antigen: A Molecule Shared by the Microenvironments of the Human Thymus and Germinal CentersDevelopmental Immunology

1993

Dermatitis herpetiformis--an autoimmune disease due to cross-reaction between dietary glutenin and dermal elastin?
Evaluation of in vivo immune complex formation and complement activation in patients receiving intravenous streptokinase.
Reciprocal changes in complement activity and immune-complex levels during plasma infusion in a C2-deficient SLE patient.

1992

Do adults with high gliadin antibody concentrations have subclinical gluten intolerance?

1991

A flow cytometric assay for measuring complement receptor 1 (CR1) and the complement fragments C3d and C4d on erythrocytesJournal of Immunological Methods

Keywords for Specialisation:

Resolution of inflammation