Skip to main content

Málstofa Lífvísindaseturs - Allele-specific expression in the human heart

Málstofa Lífvísindaseturs - Allele-specific expression in the human heart - á vefsíðu Háskóla Íslands
Hvenær 
30. september 2021 12:00 til 12:50
Hvar 

Læknagarður

stofa 343

Nánar 
Aðgangur ókeypis

Málstofa Lífvísindaseturs fimmtudaginn 30. september, kl. 12:00 í Læknagarði, stofu 343

Fyrirlesari: Dr. Martin Ingi Sigurdsson, MD, PhD, Professor of Anesthesiology and Critical Care, University of Iceland, Faculty of Medicine & Chief Physician, Department of Anesthesia and Critical Care, Landspitali University Hospital, Reykjavik, Iceland

Titill: Allele-specific expression in the human heart and its application to postoperative atrial fibrillation and myocardial ischemia

Zoom tengill: https://eu01web.zoom.us/j/67300503955

Ágrip: Differential expression between each allele of an autosomal gene, allele-specific expression (ASE), allows us to examine the biological control of gene expression in health and disease. Previously it has been shown that ASE is tissue-specific and ASE pattern of similar tissue types is similar. The ASE landscape of the human heart is poorly characterized, and few attempts have been made to use ASE to understand the pathophysiology of cardiac disease. Here we utilized two unique high-throughput RNA-seq datasets from the human left atrium (LA) and left ventricle (LV) sampled during open heart surgery to study ASE. Our hypothesis was that there was both a ASE pattern common to both chambers, as well as chamber-specific ASE. Additionally, we compared ASE pattern between patients who had postoperative atrial fibrillation (poAF) and those who did not as well as variants with differential ASE associated with the myocardial response to ischemia. Our results highlight the utility of ASE analysis to identify disease-associated variants.

Dr. Martin Ingi Sigurdsson, MD, PhD, prófessor við Læknadeild HÍ

Málstofa Lífvísindaseturs - Allele-specific expression in the human heart