Samstarf við ORF Líftækni um framleiðslu á einstofna mótefnum gegn hesta IgE frá 2003 og um framleiðslu á ofnæmisvökum í sumarexemi frá 2007, í "Quality of life and management of living resources programme Title of project: Evaluation of lentivirus DNA vaccination strategies in sheep", Sumarexem í íslenskum hestum frá árinu 2000., "Cost Food Science, Medicine and Health COST 834 program of the European Commission: Development of control programmes for small ruminant lentiviruses in Europe"

• 1988, Dr. Med.Sc, Karólinska Institutet í Stokkhólmi., Doktorspróf (Dr.Med.Sc.)
• 1979, B.Sc, Háskóli Íslands, Líffræði
• 1975, Stúdentspróf, Menntaskólinn í Reykjavík, Stúdentspróf

• 1989 - , Kom upp hybridómatækni og framleiðslu á einstofna mótefnum á Keldum, Tilraunastöð Háskóla Íslands í meinafræði að Keldum
• 2000 - , , Tilraunastöð Háskóla Íslands í meinafræði að Keldum
• 1982 - 1982, Rannsóknameinatæknir, The Wistar Institute for Anatomy and Biology í Philadelphiu, Bandaríkjunum
• 1980 - 1981, Athuganir á mótefnasvari gegn mæði/visnuveiru í kindum og meingerð í hæggengri veirusýkingu., Tilraunastöð Háskóla Íslands í meinafræði að Keldum
• 1979 - 1980, rannsóknir á tRNA genum í E. coli gerlum, Háskóli Íslands hjá Guðmundi Eggertssyni prófessor í erfðafræði

2018

• Barley produced Culicoides allergens are suitable for monitoring the immune response of horses immunized with E-coli expressed allergensVeterinary Immunology and Immunopathology
• A prospective study on insect bite hypersensitivity in horses exported from Iceland into Switzerland.Acta veterinaria Scandinavica
• Longitudinal analysis of allergen-specific IgE and IgG subclasses as potential predictors of insect bite hypersensitivity following first exposure to Culicoides in Icelandic horsesVeterinary Dermatology

2017

• Oral administration of transgenic barley expressing a Culicoides allergen induces specific antibody responseEquine Veterinary Journal
• Neonatal Immunization with a Single IL-4/Antigen Dose Induces Increased Antibody Responses after Challenge Infection with Equine Herpesvirus Type 1 (EHV-1) at Weanling AgePlos One

2016

• A preventive immunization approach against insect bite hypersensitivity: Intralymphatic injection with recombinant allergens in Alum or Alum and monophosphoryl lipid AVeterinary Immunology and Immunopathology
• Establishment and characterization of fetal equine kidney and lung cells with extended lifespan. Susceptibility to equine gammaherpesvirus infection and transfection efficiencyIn Vitro Cellular & Developmental Biology-Animal

2015

• Developing a preventive immunization approach against insect bite hypersensitivity using recombinant allergens: A pilot studyVeterinary Immunology and Immunopathology
• Antibody and cellular immune responses of naive mares to repeated vaccination with an inactivated equine herpesvirus vaccineVaccine
• Vaccination of horses against insect bite hypersensitivity: intralymphatic injection with allergens in alum or alum and monophosphoryl lipid AAllergy

2014

• Insect bite hypersensitivity of horses: induction of a specific antibody response in horses after oral treatment with transgenic barley grain expressing an insect allergenAllergy

2012

• Generation of equine TSLP-specific antibodies and their use for detection of TSLP produced by equine keratinocytes and leukocytes.Veterinary immunology and immunopathology
• Genetic diversity of equine gammaherpesviruses (γ-EHV) and isolation of a syncytium forming EHV-2 strain from a horse in Iceland.Research in veterinary science

2010

• Isolation and partial sequencing of Equid herpesvirus 5 from a horse in Iceland.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
• Skin-infiltrating T cells and cytokine expression in Icelandic horses affected with insect bite hypersensitivity: a possible role for regulatory T cells.Veterinary immunology and immunopathology
• Selective cloning, characterization, and production of the Culicoides nubeculosus salivary gland allergen repertoire associated with equine insect bite hypersensitivity.Veterinary immunology and immunopathology

2009

• Immune response against equine gammaherpesvirus in Icelandic horses.Veterinary microbiology
• Insect bite hypersensitivity in the horse: comparison of IgE-binding proteins in salivary gland extracts from Simulium vittatum and Culicoides nubeculosus.Veterinary immunology and immunopathology
• Cloning of IgE-binding proteins from Simulium vittatum and their potential significance as allergens for equine insect bite hypersensitivity.Veterinary immunology and immunopathology
• Increased IL-4 and decreased regulatory cytokine production following relocation of Icelandic horses from a high to low endoparasite environment.Veterinary immunology and immunopathology
• Identification and isolation of cDNA clones encoding the abundant secreted proteins in the saliva proteome of Culicoides nubeculosus.Insect molecular biology

2008

• Study of equid herpesviruses 2 and 5 in Iceland with a type-specific polymerase chain reaction.Research in veterinary science
• Mucosal immunization against ovine lentivirus using PEI-DNA complexes and modified vaccinia Ankara encoding the gag and/or env genes.Vaccine
• Mutational analysis of a principal neutralization domain of visna/maedi virus envelope glycoprotein.The Journal of general virology
• Systemic DNA immunization against ovine lentivirus using particle-mediated epidermal delivery and modified vaccinia Ankara encoding the gag and/or env genes.Vaccine
• In vitro analysis of expression vectors for DNA vaccination of horses: the effect of a Kozak sequence.Acta veterinaria Scandinavica
• Report of the 3rd Havemeyer workshop on allergic diseases of the Horse, Hólar, Iceland, June 2007.Veterinary immunology and immunopathology

2007

• Immune response to maedi-visna virus.Frontiers in bioscience : a journal and virtual library
• Vaccination of sheep with Maedi-visna virus gag gene and protein, beneficial or harmful?Vaccine

2006

• Equine insect bite hypersensitivity: immunoblot analysis of IgE and IgG subclass responses to Culicoides nubeculosus salivary gland extract.Veterinary immunology and immunopathology
• Production of monoclonal antibodies specific for native equine IgE and their application to monitor total serum IgE responses in Icelandic and non-Icelandic horses with insect bite dermal hypersensitivity.Veterinary immunology and immunopathology
• Evaluation of an in vitro sulphidoleukotriene release test for diagnosis of insect bite hypersensitivity in horses.Equine veterinary journal

2005

• Mucosal vaccination with an attenuated maedi-visna virus clone.Vaccine
• Simultaneous mutations in CA and Vif of Maedi-Visna virus cause attenuated replication in macrophages and reduced infectivity in vivo.Journal of virology
• Diagnostic tests for small ruminant lentiviruses.Veterinary microbiology

2004

• Cloning and sequencing of a cDNA expressing a ribosomal P0 peptide from Culicoides nubeculosus (Diptera).Veterinary immunology and immunopathology
• Transmission of small ruminant lentiviruses.Veterinary microbiology
• The vif gene of maedi-visna virus is essential for infectivity in vivo and in vitro.Virology

2003

• Intratracheal inoculation as an efficient route of experimental infection with maedi-visna virus.Research in veterinary science

1999

• Naturally occurring mutations within 39 amino acids in the envelope glycoprotein of maedi-visna virus alter the neutralization phenotype.Journal of virology

1998

• Treatment of visna virus infection in lambs with the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)adenine (PMEA).Antiviral chemistry & chemotherapy
• Visna virus dUTPase is dispensable for neuropathogenicity.Journal of virology
• Immune response to recombinant visna virus Gag and Env precursor proteins synthesized in insect cells.Virus research
• Visna in sheep as a model for chemotherapy of lentiviral central nervous system infections.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
• Biological and genetic differences between lung- and brain-derived isolates of maedi-visna virus.Virus genes
• Constitutive and visna virus induced expression of class I and II major histocompatibility complex antigens in the central nervous system of sheep and their role in the pathogenesis of visna lesions.Neuropathology and applied neurobiology

1997

• In vivo and in vitro infection with two different molecular clones of visna virus.Virology

1996

• Mimicry of a 21.5 kDa myelin basic protein peptide by a Maedi Visna virus polymerase peptide does not contribute to the pathogenesis of encephalitis in sheep.Veterinary immunology and immunopathology

1995

• Inhibitory effect of 9-(2-phosphonylmethoxyethyl)adenine on visna virus infection in lambs: a model for in vivo testing of candidate anti-human immunodeficiency virus drugs.Proceedings of the National Academy of Sciences of the United States of America

1994

• Pathogenesis of central nervous system lesions in visna cell-mediated immunity and lymphocyte subsets in blood, brain, and cerebrospinal fluid.Annals of the New York Academy of Sciences
• The effect of cyclosporin A on visna infection in sheep.Annals of the New York Academy of Sciences

1993

• Antigen processing and presentation by EBV-carrying cell lines: cell-phenotype dependence and influence of the EBV-encoded LMP1.International journal of cancer
• Over-expression of C-myc increases the sensitivity of Epstein-Barr virus immortalized lymphoblastoid cells to non-MHC-restricted cytotoxicity.International journal of cancer

1992

• Pathogenesis of central nervous system lesions in visna: cell-mediated immunity and lymphocyte subsets in blood, brain and cerebrospinal fluid.Journal of neuroimmunology

1991

• Search for the critical characteristics of phenotypically different B cell lines, Burkitt lymphoma cells and lymphoblastoid cell lines, which determine differences in their functional interaction with allogeneic lymphocytes.Cancer immunology, immunotherapy : CII
• Stimulation with allogeneic Epstein-Barr virus-transformed lymphoblastoid cell lines generates HLA class I-specific CTLs with different target cell avidity.Cellular immunology
• Human and ovine lentiviral infections compared.Comparative immunology, microbiology and infectious diseases

1989

• Allele-specific down-regulation of MHC class I antigens in Burkitt lymphoma lines.Cellular immunology
• Studies of sublines selected for loss of HLA expression from an EBV-transformed lymphoblastoid cell line. Changes in sensitivity to cytotoxic T cells activated by allostimulation and natural killer cells activated by IFN or IL-2.Journal of immunology (Baltimore, Md. : 1950)
• Reversion of tumorigenicity and decreased agarose clonability after EBV conversion of an IgH/myc translocation-carrying BL line.International journal of cancer

1988

• Combined treatment with interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha up-regulates the expression of HLA class I determinants in Burkitt lymphoma lines.Cellular immunology
• Differential expression of HLA antigens on human B-cell lines of normal and malignant origin: a consequence of immune surveillance or a phenotypic vestige of the progenitor cells?International journal of cancer

1987

• Paired Epstein-Barr virus (EBV)-negative and EBV-converted Burkitt lymphoma lines: stimulatory capacity in allogeneic mixed lymphocyte cultures.International journal of cancer
• Activation of B lymphocytes by Epstein-Barr virus/CR2 receptor interaction.European journal of immunology
• Allo-restricted cytotoxicity recognizing EBV-determined antigens. Comments.The Journal of molecular and cellular immunology : JMCI

1986

• Differentiation-dependent sensitivity of human B-cell-derived lines to major histocompatibility complex-restricted T-cell cytotoxicity.Proceedings of the National Academy of Sciences of the United States of America
• Different sensitivity of B cell lines derived from Burkitt lymphoma (BL) and normal cells (LCL) to cytotoxic T cell clones generated by autologous and allogeneic stimulation.Journal of immunogenetics
• Differential recognition of tumor-derived and in vitro Epstein-Barr virus-transformed B-cell lines by fetal calf serum-specific T4-positive cytotoxic T-lymphocyte clones.Cellular immunology

1985

• Selective inhibitory effect of Hu-IFN-gamma on the agarose clonability of tumor-derived lymphoid cell lines.Cellular immunology

1984

• Phorbol esters inhibit the functional activation of cytotoxic precursors in mixed lymphocyte cultures.Journal of immunology (Baltimore, Md. : 1950)
• T lymphocyte culture established by repeated stimulation with the autologous lymphoblastoid line. MHC class II restricted interactions with B blasts.Molecular biology & medicine
• Natural killer cell sensitivity of human lymphoid lines of B-cell origin does not correlate with tumorigenicity or with the expression of certain differentiation markers.Cellular immunology