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Forsíða

Sigrún Helga Lund - Professor

Sigrún Helga Lund

–

School of Engineering and Natural Sciences

Sigrún Helga LundShe/Her

Professor

Location
Tæknigarður / Tg-313
Phone
525 - 4636
Email
sigrunhl [at] hi.is

Unit
Faculty of Physical Sciences

Published works

2024

Application of ChatGPT for automated problem reframing across academic domainsComputers and Education: Artificial Intelligence

2023

Large-scale plasma proteomics comparisons through genetics and disease associationsNature
Comparison of medication adherence to different oral anticoagulants: population-based cohort studyBMJ open
Sequence variant affects GCSAML splicing, mast cell specific proteins, and risk of urticariaCommunications Biology
Warfarin Is Associated With Higher Rates of Upper But Not Lower Gastrointestinal Bleeding Compared with Direct Oral Anticoagulants: A Population-Based Propensity-Weighted Cohort StudyClinical Gastroenterology and Hepatology
Screening for possible hypopituitarism following mild traumatic brain injury: The first all-female study. Who do we need to evaluate further?NeuroRehabilitation

2022

Multiomics analysis of rheumatoid arthritis yields sequence variants that have large effects on risk of the seropositive subsetAnnals of the Rheumatic Diseases
Incidence of and risk factors of chronic kidney disease: results of a nationwide study in IcelandClinical Kidney Journal
Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathologyNature Communications
Multiomics study of nonalcoholic fatty liver diseaseNature Genetics
Phenotypic Displays of Cholinergic Enzymes Associate With Markers of Inflammation, Neurofibrillary Tangles, and Neurodegeneration in Pre- and Early Symptomatic Dementia SubjectsFrontiers in Aging Neuroscience
Survival, causes of death, and the prognostic role of comorbidities in chronic lymphocytic leukemia in the pre‐ibrutinib era: A population‐based studyEuropean Journal of Haematology
Large-scale comparison of immunoassay- and aptamer-based plasma proteomics through genetics and disease
Cartilage Acidic Protein 1 in Plasma Associates With Prevalent Osteoarthritis and Predicts Future Risk as Well as Progression to Joint Replacements: Results From the UK Biobank ResourceArthritis and Rheumatology
Warfarin is associated with higher rates of epistaxis compared to direct oral anticoagulants: A nationwide propensity score-weighted studyJournal of Internal Medicine
Author Correction: Rare SLC13A1 variants associate with intervertebral disc disorder highlighting role of sulfate in disc pathology (Nature Communications, (2022), 13, 1, (634), 10.1038/s41467-022-28167-1)Nature Communications
Prevalence, clinical characteristics and outcomes of hypoxic hepatitis in critically ill patientsScandinavian Journal of Gastroenterology
Comparison of the effectiveness and safety of direct oral anticoagulants: nationwide propensity score-weighted studyBlood Advances
Monitoring iron stores in Icelandic blood donors from 1997 through 2019Transfusion Medicine

2021

Loss-of-function variants in the tumor-suppressor gene PTPN14 confer increased cancer riskCancer Research
Cerebrospinal Fluid C18 Ceramide Associates with Markers of Alzheimer's Disease and Inflammation at the Pre- And Early Stages of DementiaJournal of Alzheimer's Disease
A genome-wide meta-analysis yields 46 new loci associating with biomarkers of iron homeostasisCommunications Biology
High-sensitivity troponins in dialysis patients: variation and prognostic valueClinical Kidney Journal
Rivaroxaban Is Associated With Higher Rates of Gastrointestinal Bleeding Than Other Direct Oral AnticoagulantsAnnals of Internal Medicine
Predicting the probability of death using proteomicsCommunications Biology
Fetal descent in nulliparous women assessed by ultrasound: a longitudinal studyAmerican Journal of Obstetrics and Gynecology
Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptorCommunications biology
Large-scale integration of the plasma proteome with genetics and diseaseNature Genetics
Increased risk of inflammatory bowel disease among patients treated with rituximab in Iceland from 2001 to 2018Scandinavian Journal of Gastroenterology
Pharmacokinetics of single and repeated oral doses of esomeprazole and gastrin elevation in healthy males and femalesScandinavian Journal of Gastroenterology
Can ultrasound on admission in active labor predict labor duration and a spontaneous delivery?American Journal of Obstetrics and Gynecology MFM
The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large-Scale Proteomics Scan in IcelandArthritis and Rheumatology
Genetic variants associated with platelet count are predictive of human disease and physiological markersCommunications Biology
Erratum: Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations (Cell (2021) 184(18) (4784–4818.e17), (S0092867421009417), (10.1016/j.cell.2021.07.038))Cell
Deciphering osteoarthritis genetics across 826,690 individuals from 9 populationsCell
Autoimmune disease is associated with a lower risk of progression in monoclonal gammopathy of undetermined significanceEuropean Journal of Haematology
Women and intimate partner violence: Prevalence of hospital visits and nature of injuries in the Icelandic populationScandinavian Journal of Public Health
When does fetal head rotation occur in spontaneous labor at term: results of an ultrasound-based longitudinal study in nulliparous womenAmerican Journal of Obstetrics and Gynecology

2020

Increase in the incidence of alcoholic pancreatitis and alcoholic liver disease in Iceland: impact of per capita alcohol consumptionScandinavian Journal of Gastroenterology
The prevalence of chronic kidney disease in Iceland according to KDIGO criteria and age-adapted estimated glomerular filtration rate thresholdsKidney International
Genome-wide association identifies seven loci for pelvic organ prolapse in Iceland and the UK BiobankCommunications Biology
High Mortality from Major Vascular Trauma in Traffic Accidents: A Population-Based StudyScandinavian Journal of Surgery
Predictors of Gastrin Elevation Following Proton Pump Inhibitor TherapyJournal of Clinical Gastroenterology
Suicide rates in Iceland before and after the 2008 Global Recession: A nationwide population-based studyEuropean Journal of Public Health
FLT3 stop mutation increases FLT3 ligand level and risk of autoimmune thyroid diseaseNature
Association of glial and neuronal degeneration markers with Alzheimer's disease cerebrospinal fluid profile and cognitive functionsAlzheimer's Research and Therapy
Use of proton pump inhibitors and mortality among Icelandic patients with prostate cancerBasic and Clinical Pharmacology and Toxicology
A nationwide study on hepatocellular carcinomaCancer Epidemiology
Long-term Outcome of Implantable Cardioverter/Defibrillator Lead FailureJAMA Internal Medicine

2019

GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fracturesNature Communications
Biochemical response to ursodeoxycholic acid among PBC patients: a nationwide population-based studyScandinavian Journal of Gastroenterology
A pleasant experience of peer evaluation in statistical educationTímarit kennslumiðstöðvar Háskóla Íslands
Ara h 1 and Ara h 6 Sensitization Causes Clinical Peanut Allergy in Ara h 2-Negative Individuals.International archives of allergy and immunology
The mother’s risk of premature death after child loss across two centurieseLife
Publisher Correction: GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures (Nature Communications, (2019), 10, 1, (2054), 10.1038/s41467-019-09860-0)Nature Communications
Parental longevity and survival among patients with multiple myeloma and monoclonal gammopathy of undetermined significance: a population-based studyBritish Journal of Haematology

2018

Proton pump inhibitor use and risk of breast cancer, prostate cancer, and malignant melanoma: An Icelandic population-based case-control study.Pharmacoepidemiology and drug safety
Variations in elderly peoples' visits to the emergency departments in Iceland: A five-year population studyInternational Emergency Nursing
The association between different traumatic life events and suicidality.European journal of psychotraumatology
Proton-pump inhibitors among adults: a nationwide drug-utilization studyTherapeutic Advances in Gastroenterology
Oncoplastic Breast-Conserving Surgery in Iceland: A Population-Based StudyScandinavian Journal of Surgery
Computerized algorithms compared with a nephrologist's diagnosis of acute kidney injury in the emergency department.European journal of internal medicine
ABSTINENCE FROM ALCOHOL AND ALCOHOL REHABILITATION THERAPY IN ALCOHOLIC LIVER DISEASE: A POPULATION-BASED STUDYGastroenterology
The SHA2PE score: a new score for lower gastrointestinal bleeding that predicts low-risk of hospital-based intervention.Scandinavian journal of gastroenterology
Dietary intake is associated with risk of multiple myeloma and its precursor diseasePlos One
RELATIONSHIP BETWEEN PER CAPITA ALCOHOL CONSUMPTION AND THE INCIDENCE OF ALCOHOLIC PANCREATITIS AND ALCOHOLIC LIVER DISEASE. COMPARISON BETWEEN PANCREAS DISEASE AND ALCOHOLIC LIVER DISEASEGastroenterology
Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritisNature Genetics
Views of Icelandic women towards genetic counseling - and testing of BRCA2 mutationsLaeknabladid

2017

Bone disease in monoclonal gammopathy of undetermined significance: results from a screened population-based studyBlood Advances
Suicide attempts and self-harm during a dramatic national economic transition: a population-based study in IcelandEuropean Journal of Public Health
[Fast diagnostic track for suspected lung cancer: A patient centered approach].Laeknabladid
A population-based study on epidemiology of intensive care unit treated traumatic brain injury in IcelandActa Anaesthesiologica Scandinavica
History of autoimmune disease is associated with impaired survival in multiple myeloma and monoclonal gammopathy of undetermined significance: a population-based studyAnnals of Hematology
Physical activity may decrease the likelihood of children developing constipation.Acta paediatrica (Oslo, Norway : 1992)
Reduced anticoagulation variability in patients on warfarin monitored with Fiix-prothrombin time associates with reduced thromboembolism: The Fiix-trialJournal of Thrombosis and Thrombolysis
Regional differences in mortality, hospital discharges and primary care contacts for cardiovascular diseaseScandinavian Journal of Public Health
Study of Gender Differences in Proton Pump Inhibitor Dose Requirements for GERD A Double-Blind Randomized TrialJournal of Clinical Gastroenterology
A NEW RISK SCORE AIMED AT IDENTIFYING PATIENTS WITH ACUTE LOWER GASTROINTESTINAL BLEEDING THAT DO NOT REQUIRE HOSPITAL-BASED INTERVENTIONGastroenterology
Fast diagnostic track for suspected lung cancer: A patient centered approachLaeknabladid
Obesity and risk of monoclonal gammopathy of undetermined significance and progression to multiple myeloma: a population-based studyBlood Advances
The impact of prior malignancies on second malignancies and survival in MM patients: a population-based studyBlood Advances
Editor's Choice- Diagnosis of type 2 diabetes and prediabetes among patients with acute coronary syndromesEuropean heart journal. Acute cardiovascular care
Study of Gender Differences in Proton Pump Inhibitor Dose Requirements for GERDJournal of Clinical Gastroenterology

2016

Epidemiology of the two types of gastric adenocarcinoma in Iceland according to the Laurén histological classification 1990-2009,Faraldsfrædi tveggja flokka kirtilfrumukrabbameina í maga á Íslandi samkvæmt vefjaflokkunarkerfi Laurén árin 1990-2009Laeknabladid
Warfarin as a new oral anticoagulant agent?Journal of Thrombosis and Haemostasis
Association between Daily Hydrogen Sulfide Exposure and Incidence of Emergency Hospital Visits: A Population-Based StudyPlos One
The incidence and mortality of acute thoracic aortic dissection: results from a whole nation studyEuropean Journal of Cardio-Thoracic Surgery
Free fatty acid suppositories are as effective as docusate sodium and sorbitol enemas in treating constipation in childrenActa Paediatrica
Fiix-prothrombin time monitoring improves warfarin anticoagulation outcome in atrial fibrillation: a systematic review of randomized trials comparing Fiix-warfarin or direct oral anticoagulants to standard PT-warfarinInternational Journal of Laboratory Hematology
Dialysis modality and nutritional status are associated with variability of inflammatory markersNephrology Dialysis Transplantation
Diagnosis of type 2 diabetes and prediabetes among patients with acute coronary syndromesEuropean Heart Journal: Acute Cardiovascular Care
Survival in multiple myeloma patients who develop second malignancies: a population-based cohort study.Haematologica
Risk of Progression in Monoclonal Gammopathy of Undetermined Significance (MGUS): Results from a Population-Based Screening StudyBlood
Improved Survival in AL Amyloidosis: A Population-Based Study on 1,430 Patients Diagnosed in Sweden 1995-2013Blood
Epidemiology of the two types of gastric adenocarcinoma in Iceland according to the Lauren histological classification 1990-2009Laeknabladid

2015

Topical dexamethasone -cyclodextrin nanoparticle eye drops increase visual acuity and decrease macular thickness in diabetic macular oedemaActa Ophthalmologica
Pregnancy-Induced Hypertensive Disorders before and after a National Economic Collapse: A Population Based Cohort StudyPlos One
Hodgkin lymphoma risk following infectious and chronic inflammatory diseases: a large population-based case-control study from SwedenInternational Journal of Hematology
Population-based study on the impact of the familial form of Waldenstrom macroglobulinemia on overall survivalBlood
Maternal geographic residence, local health service supply and birth outcomesActa Obstetricia Et Gynecologica Scandinavica
Information Technology and Diabetic Eye Screening: Validation, Patient Education, and Economic ImpactDiabetes
Healing Rate and Autoimmune Safety of Full-Thickness Wounds Treated With Fish Skin Acellular Dermal Matrix Versus Porcine Small-Intestine Submucosa: A Noninferiority StudyInternational Journal of Lower Extremity Wounds
The Role of Diagnosis and Clinical Follow-up of Monoclonal Gammopathy of Undetermined Significance on Survival in Multiple Myeloma.JAMA oncology
Fiix-prothrombin time versus standard prothrombin time for monitoring of warfarin anticoagulation: a single centre, double-blind, randomised, non-inferiority trialThe Lancet Haematology
Individualised risk assessment for diabetic retinopathy and optimisation of screening intervals: a scientific approach to reducing healthcare costsBritish Journal of Ophthalmology
Vitamin D and Glucose Regulation in Icelandic Patients with Acute Coronary SyndromeCardiology
The effect of SNPs on expression levels in Nimblegen RNA expression microarraysInternational Journal of Data Mining and Bioinformatics
Survival in patients with familial and sporadic myeloproliferative neoplasmsBlood
Smoking and obesity among pregnant women in Iceland 2001-2010European Journal of Public Health

2014

Estimating robustness of the tileShuffle method with repeated probesarXiv preprint arXiv:1403.3028
Patterns of Infectious Morbidity in Patients with Waldenstrom's Macroglobulinaemia/Lymphoplasmacytic Lymphoma: A Population-Based StudyBlood
Monitoring Warfarin with the Fiix-Prothrombin Time Improves Anticoagulation Stability and Long-Term Clinical Outcome. the Fiix-TrialBlood
Long term follow-up and liver-related death rate in patients with non-alcoholic and alcoholic related fatty liver diseaseBmc Gastroenterology
Emergency department visits and revisits by elderly people 2008-2012 in IcelandInternational Emergency Nursing
A Method for Detecting Long Non-Coding RNAs with Tiled RNA Expression MicroarraysPlos One
Obesity and Risk of Monoclonal Gammopathy of Undetermined Significance: A Population-Based StudyBlood
Multiple spots with the same probe on tiled RNA expression microarrays
MULTIPLE MYELOMA PATIENTS THAT DEVELOP SECOND PRIMARY MALIGNANCY HAVE A WORSE PROGNOSIS THAN MULTIPLE MYELOMA PATIENTS TREATED BEFORE THE INTRODUCTION OF NOVEL AGENTS: A POPULATION BASED-STUDYHaematologica
Kinetics of gamma-cyclodextrin nanoparticle suspension eye drops in tear fluidActa Ophthalmologica
Clinical trial: free fatty acid suppositories compared with enema as bowel preparation for flexible sigmoidoscopyFrontline Gastroenterology
Validation of a model to estimate personalised screening frequency to monitor diabetic retinopathyDiabetologia
MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE (MGUS) IS ASSOCIATED WITH A 30% INCREASED RISK OF DYING AT 8 YEARS OF FOLLOW-UP: RESULTS FROM A SCREENED CROSS-SECTIONAL POPULATION-BASED STUDYHaematologica
Dorzolamide Cyclodextrin Nanoparticle Suspension Eye Drops and Trusopt in RabbitJournal of Ocular Pharmacology and Therapeutics

2013

Bone Marrow Fibrosis In Patients With Multiple Myeloma: A New Prognostic Factor For Survival?Blood
Multiple Myeloma Patients With Prior Knowledge Of MGUS Have a Better Survival Compared To Multiple Myeloma Patients Without Prior Knowledge Of MGUSBlood
Impact Of History Of Autoimmune Disease On Survival In Multiple Myeloma Monoclonal Gammopathy Of Undetermined Significance: A Population-Based StudyBlood

2003

Analysis of time series for rock ptarmigan and gyrfalcon populations in north-east Iceland

Keywords for Specialisation:

Applied statistics