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Forsíða

Engilbert Sigurðsson - Professor

Engilbert Sigurðsson

–

Heilbrigðisvísindasvið

Engilbert Sigurðsson

Professor

Professor of Psychiatry & Consultant Psychiatrist Landspitali - The National University Hospital

Location
LSH - Hringbraut
Phone
8245345
Email
es [at] hi.is

Unit
Faculty of Medicine

Published works

2023

Methylphenidate-induced psychosis in a young adult with newly diagnosed ADHD: A case report,Geðrof í kjölfar ADHD-lyfjameðferðar: SjúkratilfelliLaeknabladid
Psychedelics and treatment of mental disorders: A survey of attitudes and knowledge among psychiatrists, general practitioners and psychologists in IcelandLæknablaðið
Genetic structure of major depression symptoms across clinical and community cohortsmedRxiv
Polygenic risk prediction: why and when out-of-sample prediction R² can exceed SNP-based heritabilityAmerican Journal of Human Genetics
Using brain cell-type-specific protein interactomes to interpret neurodevelopmental genetic signals in schizophreniaiScience

2022

Mapping genomic loci implicates genes and synaptic biology in schizophreniaNature
Symptoms, physical measures and cognitive tests after SARS-CoV-2 infection in a large population-based case-control studyResearchSquare
Symptoms, physical measures and cognitive tests after SARS-CoV-2 infection in a large population-based case-control studyResearch Square
Identifying the Common Genetic Basis of Antidepressant ResponseBiological Psychiatry Global Open Science
Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk FactorsBiological Psychiatry
Thirty novel sequence variants impacting human intracranial volumeBrain Communications

2021

Case Report: Successful Implementation of Integrative Cognitive Remediation for Early PsychosisFrontiers in Psychiatry
Evaluation of mechanism of change in transdiagnostic cognitive behaviour therapy using single case experimental designJournal of Behavior Therapy and Experimental Psychiatry
Sex-Dependent Shared and Nonshared Genetic Architecture Across Mood and Psychotic Disorders.Biological psychiatry
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology.Nature genetics
HLA-DQB1 6672G>C (rs113332494) is associated with clozapine-induced neutropenia and agranulocytosis in individuals of European ancestry.Translational psychiatry
Bipolar multiplex families have an increased burden of common risk variants for psychiatric disordersMolecular Psychiatry
Correction: Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank (Molecular Psychiatry, (2020), 25, 7, (1430-1446), 10.1038/s41380-019-0546-6)Molecular Psychiatry
Association of polygenic score for major depression with response to lithium in patients with bipolar disorderMolecular Psychiatry
Trail making test, stroop, and verbal fluency: Regression-based norms for the Icelandic populationArchives of Clinical Neuropsychology
Genetic propensities for verbal and spatial ability have opposite effects on body mass index and risk of schizophreniaIntelligence
A Comparison of Ten Polygenic Score Methods for Psychiatric Disorders Applied Across Multiple CohortsBiological Psychiatry

2020

Integrative cognitive remediation for early psychosis: A 12-month follow-upPsychiatry Research
Schizophrenia, cognition, and aging: cognitive deficits and the relationship between test performance and agingAging, Neuropsychology, and Cognition
A comparison of ten polygenic score methods for psychiatric disorders applied across multiple cohortsmedRxiv
‘You should always look at the washing machine without actually being in it!’ Thematic framework analysis of patients’ understanding of transdiagnostic cognitive behaviour therapy and its mechanismsPsychology and Psychotherapy: Theory, Research and Practice
Use of serotonin reuptake inhibitors is not associated with increased bleeding after CABGGeneral Thoracic and Cardiovascular Surgery
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individualsNature Genetics
Innovations and challenges in medical education in times of burgeoning software evolution,Nýjungar og áskoranir í læknanámi á tímum rafrænna stökkbreytingaLaeknabladid
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK BiobankNature Communications
Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK BiobankMolecular Psychiatry
Complement genes contribute sex-biased vulnerability in diverse disordersNature
Árangur ADHD-lyfjameðferðar fullorðinna í ADHD-teymi Landspítala 2015-2017Læknablaðið
Should Patients' Values Be Discussed in Relation to Long-Term Blood Monitoring Before and During Clozapine Treatment?Journal of clinical psychopharmacology
Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With DepressionBiological Psychiatry
The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 ControlsBiological Psychiatry

2019

A polygenic resilience score moderates the genetic risk for schizophrenia.Molecular psychiatry
Integrative cognitive remediation for early psychosis: Results from a randomized controlled trialPsychiatry Research
Sequence variants with large effects on cardiac electrophysiology and diseaseNature Communications
High altitude illness and related diseases - a reviewLaeknabladid
Gene expression imputation across multiple brain regions provides insights into schizophrenia riskNature Genetics
Trail Making Test, Stroop, and Verbal Fluency: Regression-Based Norms for the Icelandic PopulationArchives of Clinical Neuropsychology
Publisher Correction: Gene expression imputation across multiple brain regions provides insights into schizophrenia risk (Nature Genetics, (2019), 51, 4, (659-674), 10.1038/s41588-019-0364-4)Nature Genetics
Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-bornsNature Communications
Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection (Nature Genetics, (2018), 50, 3, (381-389), 10.1038/s41588-018-0059-2)Nature Genetics
Identification of common genetic risk variants for autism spectrum disorderNature Genetics
Cognitive measures and performance on the antisaccade eye movement taskJournal of Cognition
Genome-wide association study identifies 30 loci associated with bipolar disorderNature Genetics
Population-based identity-by-descent mapping combined with exome sequencing to detect rare risk variants for schizophreniaAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics
Association of Whole-Genome and NETRIN1 Signaling Pathway–Derived Polygenic Risk Scores for Major Depressive Disorder and White Matter Microstructure in the UK BiobankBiological Psychiatry: Cognitive Neuroscience and Neuroimaging
Social and non‐social measures of cognition for predicting self‐reported and informant‐reported functional outcomes in early psychosisScandinavian Journal of Psychology
Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric DisordersCell
Assessment of bidirectional relationships between physical activity and depression among adults a 2-sample Mendelian randomization studyJAMA Psychiatry
Attention-deficit hyperactivity disorder shares copy number variant risk with schizophrenia and autism spectrum disorderTranslational Psychiatry

2018

A correction for sample overlap in genome-wide association studies in a polygenic pleiotropy-informed frameworkBMC Genomics
Applying polygenic risk scoring for psychiatric disorders to a large family with bipolar disorder and major depressive disorderCommunications Biology
Does Childhood Trauma Moderate Polygenic Risk for Depression? A Meta-analysis of 5765 Subjects From the Psychiatric Genomics ConsortiumBiological Psychiatry
Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorderPLoS ONE
Improving genetic prediction by leveraging genetic correlations among human diseases and traitsNature Communications
Constipation, ileus and medication use during clozapine treatment in patients with schizophrenia in IcelandNordic Journal of Psychiatry
Age at first birth in women is genetically associated with increased risk of schizophreniaScientific Reports
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 SubphenotypesCell
Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selectionNature Genetics
Polygenic risk scores for schizophrenia and bipolar disorder associate with addictionAddiction biology
Estimation of Genetic Correlation via Linkage Disequilibrium Score Regression and Genomic Restricted Maximum LikelihoodThe American Journal of Human Genetics
A Randomized, Controlled Trial on Integrated Cognitive Remediation for Early Psychosis: Effectiveness and Factors Associated with Treatment ResponseEARLY INTERVENTION IN PSYCHIATRY
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depressionNature Genetics

2017

Risk of diabetes and dyslipidemia during clozapine and other antipsychotic drug treatment of schizophrenia in IcelandNordic Journal of Psychiatry
Genome-wide Association for Major Depression Through Age at Onset Stratification: Major Depressive Disorder Working Group of the Psychiatric Genomics ConsortiumBiological Psychiatry
15q11.2 CNV affects cognitive, structural and functional correlates of dyslexia and dyscalculiaTranslational Psychiatry
Genetic correlation between amyotrophic lateral sclerosis and schizophreniaNature Communications
Methylphenidate disintegration from oral formulations for intravenous use by experienced substance usersDrug and Alcohol Dependence
Truncating mutations in RBM12 are associated with psychosisNature Genetics
Hair Cortisol in Twins: Heritability and Genetic Overlap with Psychological Variables and Stress-System GenesScientific Reports
Genetic Overlap Between Attention-Deficit/Hyperactivity Disorder and Bipolar Disorder: Evidence From Genome-wide Association Study Meta-analysisBiological Psychiatry
Reproductive fitness and genetic risk of psychiatric disorders in the general populationNature Communications
Genetic association of major depression with a typical features and obesity-related immunometabolic dysregulationsJAMA Psychiatry

2016

Neutropenia and agranulocytosis during treatment of schizophrenia with clozapine versus other antipsychotics: an observational study in IcelandBMC Psychiatry
Clozapine treatment and discontinuation in Iceland: A national longitudinal study using electronic patient recordsNordic Journal of Psychiatry
Intravenous Use of Prescription Psychostimulants; A Comparison of the Pattern and Subjective Experience between Different Methylphenidate Preparations, Amphetamine and CocaineEuropean Addiction Research
A new chapter [Editorial]Laeknabladid
Multimorbidity and use of hypnotic and anxiolytic drugs: Cross-sectional and follow-up study in primary healthcare in IcelandBMC Family Practice
No Reliable Association between Runs of Homozygosity and Schizophrenia in a Well-Powered Replication StudyPLoS Genetics
KaflaskilLæknablaðið

2015

The association between lower educational attainment and depression owing to shared genetic effects? Results in ∼25 000 subjectsMolecular Psychiatry
LD score regression distinguishes confounding from polygenicity in genome-wide association studiesNature Genetics
Að höggva undan sér fæturnaLæknablaðið
Prevalent intravenous abuse of methylphenidate among treatment-seeking patients with substance abuse disorders: A descriptive population-based studyJournal of Addiction Medicine
[Destabilising the foundations of health and safety [Editorial]].
Prevalent Intravenous Abuse of Methylphenidate Among Treatment-Seeking Patients With Substance Abuse DisordersJournal of Addiction Medicine
Modeling Linkage Disequilibrium Increases Accuracy of Polygenic Risk ScoresAmerican Journal of Human Genetics
Polygenic risk scores for schizophrenia and bipolar disorder predict creativityNature Neuroscience
Transdiagnostic cognitive behavioural treatment and the impact of co-morbidity: An open trial in a cohort of primary care patientsNordic Journal of Psychiatry

2014

Emetophobia: Morbid fear of vomiting and nausea,Emetophobia: Sjúklegur ótti vio uppköst og ógleoiLaeknabladid
Common variant at 16p11.2 conferring risk of psychosisMolecular Psychiatry
Variability inworking memory performance explained by epistasis vs polygenic scores in the ZNF804A pathwayJAMA Psychiatry
Biological insights from 108 schizophrenia-associated genetic lociNature
Identification of pathways for bipolar disorder: A meta-analysisJAMA Psychiatry
Does the use of cannabis increase the risk for psychosis and the development of schizophrenia?,Eykur notkun kannabis hættu á gedrofi og próun gedklofa?Laeknabladid
Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility geneMolecular Psychiatry
CNVs conferring risk of autism or schizophrenia affect cognition in controlsNature
Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseasesAmerican Journal of Human Genetics

2013

Risk of disasters in LandspitalaLaeknabladid
Schizophrenia genetic variants are not associated with intelligencePsychological Medicine
Evaluation of the Psychometric Properties of the Icelandic Version of the Clinical Outcomes in Routine Evaluation-Outcome Measure, its Transdiagnostic Utility and Cross-Cultural ValidationClinical Psychology & Psychotherapy
Opening Pandora's box in the UK: A hypothetical pharmacogenetic test for clozapinePharmacogenomics
Genome-wide association analysis identifies 13 new risk loci for schizophreniaNature Genetics
The effect of antidepressants and sedatives on the efficacy of transdiagnostic cognitive behavioral therapy in groups in primary care,Áhrif punglyndislyfja og róandi lyfja á árangur af ósértÆkri hugrÆnni atferlismeofero hópa í heilsugÆsluLaeknabladid
A mega-Analysis of genome-wide association studies for major depressive disorderMolecular Psychiatry
All SNPs Are Not Created Equal: Genome-Wide Association Studies Reveal a Consistent Pattern of Enrichment among Functionally Annotated SNPsPlos Genetics
Opening Pandora’s box in the UK: a hypothetical pharmacogenetic test for clozapinePharmacogenomics
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysisLancet
Genetic schizophrenia risk variants jointly modulate total brain and white matter volumeBiological Psychiatry
[Risk of a crisis developing at Landspítali].,Hserra á neydarástandi á landspítala.Læknabladid

2012

Response to Boot et al. LetterAmerican Journal of Psychiatry
Association between genetic variation in a region on chromosome 11 and schizophrenia in large samples from EuropeMolecular Psychiatry
Association study of nonsynonymous single nucleotide polymorphisms in schizophreniaBiological Psychiatry
Replication study and meta-analysis in European samples supports association of the 3p21.1 locus with bipolar disorderBiological Psychiatry

2011

[Human nature and the development of scientific journals].Laknabladid
At-risk variant in TCF7L2 for type II diabetes increases risk of schizophreniaBiological Psychiatry
Candidate gene analysis of the human natural killer-1 carbohydrate pathway and perineuronal nets in schizophrenia: B3GAT2 Is associated with disease risk and cortical surface areaBiological Psychiatry
Developments in schizophrenia genetics: From linkage to microchips, deletions and duplicationsNordic Journal of Psychiatry
Genome-wide association study identifies five new schizophrenia lociNature Genetics
Copy number variations of chromosome 16p13.1 region associated with schizophreniaMolecular Psychiatry
Common variants on 8p12 and 1q24.2 confer risk of schizophreniaNature Genetics
Early detection of prostate cancer: Is screening in general practice justifiable?Scandinavian Journal of Primary Health Care
[The Journal's progress and threats to the welfare of patients [Editorial]].Laknabladid
Expanding the range of ZNF804A variants conferring risk of psychosisMolecular Psychiatry
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4Nature Genetics
Back to the past. Case report and review on retrograde memory lossLaeknabladid
Efficacy of cognitive behavioral therapy in the treatment of mood and anxiety disorders in adultsLaeknabladid
Maternally derived microduplications at 15q11-q13: Implication of imprinted genes in psychotic illnessAmerican Journal of Psychiatry
Common variants at VRK2 and TCF4 conferring risk of schizophreniaHuman Molecular Genetics
Mirror extreme BMI phenotypes associated with gene dosage at the chromosome 16p11.2 locusNature
Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder (The American Journal of Human Genetics (2011) 88, (372-381))American Journal of Human Genetics
Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorderAmerican Journal of Human Genetics

2010

Catechol-o-methyltransferase val¹⁵⁸met polymorphism and antisaccade eye movements in schizophreniaSchizophrenia Bulletin
Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohortJournal of Psychiatric Research
S100B Profiles and Cognitive Function at High AltitudeHigh Altitude Medicine & Biology
Hlutverk lækna í hagrædingu innan heilbrigdiskerfisins: Gagnsæi, ord og efndirLaeknabladid

2009

Scientific articles in the Icelandic Medical Journal 2004-2008: An overview,Hverjir skrifa í Læknablaoio?: Yfirlit yfir fræ Oigreinar sí oustu fimm áraLaeknabladid
[Public views on antidepressant treatment: lessons from a national survey].Laknabladid
COMT val158met genotype and smooth pursuit eye movements in schizophreniaPsychiatry Research
FÍFLagangur ad voriLaeknabladid
Loss, appreciation and regret,Enginn veit hvad átt hefur fyrr en misst hefurLaeknabladid
Neuregulin-1 genotypes and eye movements in schizophreniaEuropean Archives of Psychiatry and Clinical Neuroscience
[Scientific articles in the Icelandic Medical Journal 2004-2008: an overview].Laknabladid
Disruption of the neurexin 1 gene is associated with schizophreniaHuman Molecular Genetics
[Loss, appreciation and regret].Laknabladid
Common variants conferring risk of schizophreniaNature

2008

Vacuum-Assisted Closure for Successful Treatment of a Major Contaminated Gunshot Chest-Wound: A Case ReportEuropean Journal of Trauma and Emergency Surgery
Eye movement deficits in schizophreniaEuropean Archives of Psychiatry and Clinical Neuroscience
Large recurrent microdeletions associated with schizophreniaNature
Public views on antidepressant treatment: Lessons from a national surveyNordic Journal of Psychiatry
[Odds, fate and fortunes].Laknabladid

2007

Neuregulin-1 risk haplotype and eye movements in schizophreniaEuropean Neuropsychopharmacology
Support for involvement of the AHI1 locus in schizophreniaEuropean Journal of Human Genetics
Oculomotor deficits in schizophrenia: Validation of endophenotypes in a genetically homogenous Icelandic sampleEuropean Psychiatry
Cathechol-o-methyltransferase polymorphism and eye movements in schizophreniaEuropean Neuropsychopharmacology
Cognitive function in schizophrenia and effects of neuregulin 1Schizophrenia Bulletin

2006

Health-related quality of life of patients with implantable cardioverter defibrillators compared with that of pacemaker recipientsEP Europace
Neuregulin-1 risk genotype and eye movements in schizophreniaAmerican Journal of Medical Genetics Part B-Neuropsychiatric Genetics
Neuregulin-1 and eye movements in schizophreniaSchizophrenia Research
Neuregulin 1 and cognitive function in schizophreniaSchizophrenia Research
Gene in common to schizophrenia and bipolar disorder mapped to 17q21.31-q22American Journal of Medical Genetics Part B-Neuropsychiatric Genetics

2005

Views on antidepressants among adults in Iceland: a population-based surveyEuropean Neuropsychopharmacology

2004

Genetic loading in schizophrenia in relation to the at-risk haplotype of the NRG1 geneNordic Journal of Psychiatry
The deficit syndrome of schizophrenia and neuregulin1Schizophrenia Research
Genomics and genealogy provide an Icelandic springboard into the human gene poolJournal of Mental Health

2003

Neuregulin 1 detected as a susceptibility gene in schizophreniaNordic Journal of Psychiatry
Schizophrenia genes identified by positional cloning affect the glutamatergic systemEuropean Neuropsychopharmacology

2002

Are Impaired Childhood Motor Skills a Risk Factor for Adolescent Anxiety? Results From the 1958 U.K. Birth Cohort and the National Child Development StudyAmerican Journal of Psychiatry
Neuregulin 1 and Susceptibility to SchizophreniaAmerican Journal of Human Genetics
Childhood motor impairment and persistent anxiety in adolescent boysEuropean Psychiatry

2001

Family matters: interfaces between child and adult mental health.Acta Psychiatrica Scandinavica

1999

Neurodevelopmental delay in the severely ill [8] (multiple letters)British Journal of Psychiatry
Neurodevelopmental delay in the severely ill - Authors' replyBritish Journal of Psychiatry
Neurodevelopmental antecedents of early-onset bipolar affective disorderBritish Journal of Psychiatry

1994

The effects of electroconvulsive therapy and depression on confabulation, memory processing, and suggestibilityNordic Journal of Psychiatry
VALUE OF ANTIBODIES TO GAD(65) COMBINED WITH ISLET-CELL CYTOPLASMIC ANTIBODIES FOR PREDICTING IDDM IN A CHILDHOOD POPULATIONDiabetologia

1990

THE 64-KDA BETA-CELL MEMBRANE AUTOANTIGEN AND OTHER TARGET MOLECULES OF HUMORAL AUTOIMMUNITY IN INSULIN-DEPENDENT DIABETES-MELLITUSCurrent Topics in Microbiology and Immunology
The 64-kDa beta cell membrane autoantigen and other target molecules of humoral autoimmunity in insulin-dependent diabetes mellitusCurrent Topics in Microbiology and Immunology

1989

PREDICTIVE VALUE OF 64K ANTIBODIES FOR IDDM IN A CHILDHOOD POPULATIONScandinavian Journal of Immunology
PREDICTIVE VALUE OF MR 64000 ANTIBODIES FOR TYPE-1 (INSULIN-DEPENDENT) DIABETES IN A CHILDHOOD POPULATIONDiabetologia
EXPRESSION OF THE 64K AUTO-ANTIGEN AND A NOVEL TARGET OF DIABETIC AUTOANTIBODIES IN ISLETS OF DIABETES PRONE BB-RATSScandinavian Journal of Immunology

Keywords for Specialisation:

Genetics - psychiatry - epidemiology

Genetics - psychiatry - epidemiology - open online courses - personalised medicine