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Stefán Þórarinn Sigurðsson - Prófessor

Stefán Þórarinn Sigurðsson

–

Heilbrigðisvísindasvið

Stefán Þórarinn Sigurðsson

Prófessor

Prófessor í lífefna- og sameindalíffræði

Aðsetur
Sturlugata 8
Sími
5254839
Tölvupóstur
stefsi [hjá] hi.is

Starfseining
Læknadeild, Lífefnafræði

ORCID vefsíða
https://orcid.org/0000-0002-5284-0058
Rannsóknagátt – Stefán Þórarinn Sigurðsson

Útgefið efni

2023

Estrogen receptor-positive breast cancer and adverse outcome in BRCA2 mutation carriers and young non-carrier patientsnpj Breast Cancer

2020

Breast cancer survival in Nordic BRCA2 mutation carriers—unconventional association with oestrogen receptor statusBritish Journal of Cancer
BRCA1 Promoter Methylation Status in 1031 Primary Breast Cancers Predicts Favorable Outcomes Following ChemotherapyJNCI Cancer Spectrum

2019

Epigenetic inactivation of the splicing RNA-binding protein CELF2 in human breast cancer.Oncogene
CpG promoter hypo-methylation and up-regulation of microRNA-190b in hormone receptor-positive breast cancer.Oncotarget

2018

Association of brca2 k3326∗ with small cell lung cancer and squamous cell cancer of the skinJournal of the National Cancer Institute
Northern lights assay: a versatile method for comprehensive detection of DNA damageNucleic Acids Res.

2017

CpG promoter methylation of the ALKBH3 alkylation repair gene in breast cancerBMC Cancer

2010

Evidence that Transcript Cleavage Is Essential for RNA Polymerase II Transcription and Cell ViabilityMolecular Cell
Transcript Elongation by RNA Polymerase IIAnnual Review of Biochemistry, Vol 79

2009

Distinct ubiquitin ligases act sequentially for RNA polymerase II polyubiquitylationProceedings of the National Academy of Sciences of the United States of America

2008

Reversal of RNA polymerase II ubiquitylation by the ubiquitin protease ubp3Molecular Cell
Sensing transcription problems: the RNA polymerase II ubiquitylation system targets backtracked elongation complexesFebs Journal

2007

Communication between distant sites in RNA polymerase II through ubiquitylation factors and the polymerase CTDCell

2006

Differential contributions of mammalian Rad54 paralogs to recombination, DNA damage repair, and meiosisMolecular and Cellular Biology
Roles of ATP binding and ATP hydrolysis in human Rad51 recombinase functionDNA Repair

2004

Human meiotic recombinase Dmc1 promotes ATP-dependent homologous DNA strand exchangeNature

2002

Functional cross-talk among Rad51, Rad54, and replication protein A in heteroduplex DNA joint formationJournal of Biological Chemistry
Homologous DNA pairing by human recombination factors Rad51 and Rad54Journal of Biological Chemistry

2001

Basis for avid homologous DNA strand exchange by human Rad51 and RPAJournal of Biological Chemistry
Mediator function of the human Rad51B-Rad51C complex in Rad51/RPA-catalyzed DNA strand exchangeGenes & Development

2000

Superhelicity-driven homologous DNA pairing by yeast recombination factors Rad51 and Rad54Molecular Cell
p53 abnormality and chromosomal instability in the same breast tumor cellsCancer Genetics and Cytogenetics

1998

BRCA2 and p53 mutations in primary breast cancer in relation to genetic instabilityCancer Research
Simultaneous detection of p53 nuclear protein and chromosome aberrations on sections from formalin-fixed, paraffin-embedded breast cancer tissueChromosome Research
BRCA2 and p53 mutations in primary breast cancer in relation to genetic instabilityCancer Research
A study on BRCA2 and p53 mutations in primary breast carcinomasEuropean Journal of Human Genetics
BRCA2 germline mutations in Swedish breast cancer familiesEuropean Journal of Human Genetics

1997

BRCA2 mutation in Icelandic prostate cancer patientsJournal of Molecular Medicine-Jmm
Study of a single BRCA2 mutation with high carrier frequency in a small populationAmerican Journal of Human Genetics
Study of a single BRCA2 mutation with high carrier frequency in a small populationAmerican Journal of Human Genetics

Sérsvið:

DNA endurröðun

Brjóstakrabbamein

Eggjastokkakrabbamein

Brjóstakrabbamein í körlum

Sviperfðabreytingar

Epitranscriptomics